The REDUCE MRSA Trial (Randomized Evaluation of Decolonization vs. Universal Clearance to Eliminate Methicillin-Resistant Staphylococcus aureus) found that universal decolonization was the most effective intervention to reduce MRSA infections. This enhanced protocol provides instructions for implementing universal decolonization in adult intensive care units.
Prepared for:
Agency for Healthcare Research and Quality 
Rockville, MD
Centers for Disease Control and Prevention 
Atlanta, GA
Contract No. HHSA290201000008i
Prepared by:
The REDUCE MRSA Trial Working Group 
Harvard Pilgrim Health Care 
University of California Irvine 
Hospital Corporation of America
Authors
University of California Irvine 
Susan Huang, MD, MPH 
Adrijana Gombosev, BS 
Leah Terpstra, BA
Harvard Pilgrim Health Care 
Richard Platt, MD, MS 
Julie Lankiewicz, MPH, CCRC 
Katie Haffenreffer, BS
Hospital Corporation of America (HCA) 
Edward Septimus, MD 
Jason Hickok, MBA, RN 
Julia Moody, MS 
Jonathan Perlin, MD, PhD
John Stronger Hospital of Cook County 
Robert Weinstein, MD
Rush University 
Mary Hayden, MD
Centers for Disease Control and Prevention 
Jonathan Jernigan, MD, MPH
Preparation of this enhanced protocol was supported by the Agency for Healthcare Research and Quality (AHRQ) through contract HHSA290201000008i. The opinions presented herein are those of the authors and do not necessarily represent the position of the U.S. Department of Health and Human Services, AHRQ, or the Centers for Disease Control and Prevention (CDC).
This protocol is in the public domain and may be reproduced and distributed without permission. Citation as to source is appreciated.